3.20 path Flashcards

(41 cards)

0
Q

Centrilobular necrosis

A

Liver congestion

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1
Q

Gamna Gandy bodies / siderofibrotic bodies

A

Congestion of spleen

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2
Q

Heart failure cells

A

Chronic lung congestion (is hemosiderin laden macrophages)

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3
Q

Virchow Robbins

A

Peri vascular space in cerebral edema

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4
Q

Serosanguinous fluid

A

When cut lung with pulmonary edema

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5
Q

Bibasilar rales

A

Symptom of pulmonary edema

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6
Q

Petechiae

A

Disorder of platelets

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7
Q

Purpura, think

A

Vasculitis

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8
Q

Ecchymosis

A

Factor deficiency

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9
Q

Vasoconstrictor

A

Endothelin

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10
Q

What activates protein c?

A

Thrombomodulin with thrombin

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11
Q

Vasodilators that prevent platelet adherence and aggregation

A

PGI2

NO

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12
Q

What binds heparin

A

Antithrombin

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13
Q

TFPI

A

Binds and inhibits factor 7 and 10

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14
Q

Protein c inhibits

A

PAI1

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15
Q

Protein c inactivated what factors

A

5,8

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16
Q

tPA

A

Plasminogen to plasmin

17
Q

What prevents fibrinolysis

18
Q

Congenital lack of alpha granules

A

Gray platelet syndrome

19
Q

What is in alpha granules

A

Fibrinogen
Factor 5,8
vWF

20
Q

What’s in dense bodies / delta granules

A

ADP
ATP
Ionized calcium

21
Q

What activates platelets

22
Q

Abnormal GP-Ib

A

Bernard Soulier Syndrome

23
Q

Vasoconstrictors

24
What molecule allows platelets to stick together
Fibrinogen
25
Abnormal GP IIb-IIIa
Glanzmann thrombasthenia
26
Activator of secondary hemostasis / coag cascade
Tissue factor bound to factor 7
27
Problem with secondary hemostasis (coag cascade) results in
Hematoma | Hemarthrosis
28
Extrinsic pathway also called
Tissue factor pathway
29
Intrinsic pathway also called
Contact factor pathway
30
INR standardized the
PT
31
If you have normal PT and PTT but you know you have a coag cascade problem, what could be wrong
Factor 13 (involved with fibrin cross links)
32
4 components of coag cascade
Active enzyme Cofactors Calcium Phospholipid surface
33
What enzyme creates d dimers
Plasmin
34
Inhibit plasmin
PAI1&2 | Alpha 2 antiplasmin
35
What inhibits factors 2,7,9,10,11,12
ATIII (anti thrombin)
36
If give heparin without incr PTT you have a deficiency in
ATIII
37
Factor V Leiden associated with
Protein c
38
What is included in PTT but get no bleeding disorder
Factor 12 (hageman factor)
39
Anti phospholipid syndrome
Ab against phospholipid Prolongs PTT Causes thrombosis
40
What can distinguish pre and post mortem clots
Lines of zahn