Mucoactive Drugs

Question 0

Mucoregulators - defn and examples

Answer 0

Control mucus hyper secretion

Carbocysteine
Anticholinergics
Glucocorticoids
Macrolides

Question 1

Expectorants - defn and examples

Answer 1

Expels mucus thru coughing or sneezing

Hypertonic saline
Guaifenesin

Question 2

Mucolytics - defn and examples

Answer 2

Break down structure of mucus reducing viscosity and elasticity

Acetylcysteine
Erdocysteine
Dornase alfa

Question 3

Mucokinetics - defn and examples

Answer 3

Increase mobility and transportability of mucus

Bronchodilators
Surfactants

Question 4

2 ILs affected by hypertonic saline

Answer 4

IL37 anti microbial

IL8 proinflammatory

Question 5

Increases water movement by osmosis

Answer 5

Hypertonic saline

Question 6

GAGs inhibit what IL

Answer 6

IL37 (anti microbial) but hypertonic saline releases it from GAG

Question 7

GAGs prevent degradation of

Answer 7

IL8 (pro inflamm) but hypertonic saline releases IL8 from GAGs

Question 8

Stimulates gastric nerve

Answer 8

Guaifenesin

Question 9

Promotes vagally mediated increase in airway secretions

Answer 9

Guaifenesin

Question 10

Nephrolithiasis in high doses

Answer 10

Guaifenesin

Question 11

Safe and well tolerated

Answer 11

Carbocysteine

Question 12

Increases Cl transport across airway epithelium

Answer 12

Carbocysteine

Question 13

Increases ciliary beat freq in COPD

Answer 13

Anticholinergics

Question 14

Reduces airway inflammation and therefore mucus secretion

Answer 14

Glucocorticoids

Question 15

Long term oral admin decreases water and mucus secretion

Answer 15

Macrolides

Question 16

Causes tachycardia, dry mouth, urinary retention, glaucoma

Answer 16

Anticholinergics

Question 17

Contains EDTA

Answer 17

Acetylcysteine

Question 18

Used for atelectasis

Answer 18

Acetylcysteine

Question 19

Used for bronchitis

Answer 19

Acetylcyteine

Question 20

Antidote for acetaminophen toxicity

Answer 20

Acetylcysteine

Question 21

Unpleasant odor

Answer 21

Acetylcysteine

Question 22

Can cause bronchospasms

Answer 22

Acetylcysteine

Question 23

For Bronchiectasis

Answer 23

Erdosteine

Question 24

Is an orphan drug

Answer 24

Erdosteine

Question 25

Lyses DNA bonds in sputum

Answer 25

Dornase alfa

Question 26

Can cause voice alteration

Answer 26

Dornase alfa

Question 27

CI in patients hypersensitive to chinese hamster

Answer 27

Dornase alfa

Question 28

Inhibit PDE and increase cAMP

Answer 28

Bronchodilators

Question 29

For RDS

Answer 29

Surfactants

Question 30

2 surfactant drugs

Answer 30

Lucinactant | Calfactant

Question 31

What drug requires manual ventilation

Answer 31

Calfactant

Question 32

Can cause bradycardia

Answer 32

Calfactant

Question 33

Used for CF in patients 6+ with G551D mutation

Answer 33

Ivacaftor

Question 34

Increases Cl transport by opening Cl channel

Answer 34

Ivacaftor