3 path cv 2 Flashcards
(26 cards)
Blood pressure regulation
Renin angiotensin
ATII increases TPR
aldosterone increases sodium reabs
NO release
Natriuretic factors inhibit sodium reabs
Malignant hypertension bp
Over 200/120
Onion skinning
Hyperplastic arteriolosclerosis
Hyaline arteriolosclerosis common in
Hypertensive
Diabetics
Hyperplastic arteriolosclerosis common in
Malignant hypertension
What thickens in hypertension
Afferent arteriole
3 types of arteriosclerosis
Atherosclerosis
Arteriolosclerosis
Monckeberg medial sclerosis
Earliest lesion of atherosclerosis
Fatty streaks
Fatty streaks composed of
Lipid filled foam cells
Complications of atherosclerosis
Calcification
Ulceration
Thrombosis
Aneurysm
Early and late processes of plaque formation
Early: intimal thickening
Late: atheroma formation
Atheroma
Raised fibrous lesion in intima
Soft yellow lipid core
3 principal components of atherosclerotic plaques
Cells (smooth m cells, macro, leuko)
ECM (collagen, elastic fibers, proteoglyc)
Lipids
Thrombosis usually occurs on
Disrupted lesions
Consequences of atherosclerosis
MI
Stroke
Peripheral vasc disease (gangrene)
AAA
Tree barking
Syphilitic aneurysm
True aneurysm
Bound by arterial wall
False aneurysm
Defect of vascular wall
Mycotic aneurysm
Infection of artery that weakens the wall
Saccular aneurysm
Round
Fusiform aneurysm
Cigar like
Aneurysm below renal arteries
Abdominal aortic aneurysm
Consequences of AAA
Hemorrhage Obstruct vessel Embolism Impinge adjacent structures Pulsates
Clinical consequences of thoracic aortic aneurysm
Compress mediastinum Breathe difficult Can't swallow well Cough Aortic valve dialation Rupture
