3.17 neoplasia childhood

Question 0

Can cause low platelets

Answer 0

Capillary or cavernous hemangioma

Question 1

Might have VHL

Answer 1

Capillary hemangioma

Cavernous hemangioma

Question 2

Can cause cardiac stress if too large

Answer 2

Capillary or cavernous hemangioma

Question 3

Cavernous lymphatic spaces in neck, mediastinum, retroperitoneum, axillary

Answer 3

Lymphangioma

Question 4

Swollen extremities

Answer 4

Lymphangiectasia

Question 5

Low cellularity

Answer 5

Fibromatosis / desmoid tumor

Question 6

Highly cellular

Answer 6

Congenital infantile fibrosarcoma

Question 7

t(12;15)

Answer 7

Congenital infantile fibrosarcoma

Question 8

Incidence of teratomas what age

Answer 8

<2 or late adolescence

Question 9

Sites of teratomas

Answer 9

Sacrococcygeal
Testis/ovary
Midline (head/neck, mediastinum, retroperitoneal)

Question 10

Histology of malignant tumors

Answer 10

Small round blue cell

Question 11

Retinoblastoma histo

Answer 11

Flexner wintersteiner rosettes

Question 12

Histo neuroblastic tumors

Answer 12

Homer wright pseudorosettes

Question 13

Neuroblastic tumors affect what / have tumors in what location

Answer 13

Sympathetic ganglia

Adrenal medulla

Question 14

Neuroblasic tumors derived from

Answer 14

Neural crest cells

Question 15

Blueberry muffin baby has

Answer 15

Neuroblastic tumors

Question 16

FISH of MYC amplification

Answer 16

Unfavorable for neuroblastic tumor

Question 17

Near normal ploidy

Answer 17

Unfavorable for neuroblastic tumor

Question 18

Schwannian stroma or ganglion cells

Answer 18

Favorable outcome for neuroblastic tumors

Question 19

Age cutoff for good vs bad prognosis for neuroblastic tumors

Answer 19

18 months (good if younger)

Question 20

Most important prognostic indicator for neuroblastic tumors

Answer 20

N-MYC oncogene

Question 21

Most common malignant tumor of infancy

Answer 21

Neuroblastic tumor

Question 22

Most common tumor in infancy

Answer 22

Hemangiomas

Question 23

Anaplastic histology prognosis

Answer 23

Bad prognosis of Wilms tumor

Question 24

Precursor lesions to Wilms tumor

Answer 24

Neohrogenic rests

Question 25

Gonadal dysgenesis

Answer 25

Denys-Drash syndrome (associated with Wilms tumor)

Question 26

PAX6 gene causes

Answer 26

Sporadic aniridia | WAGR if also have Wilms tumor

Question 27

WAGR syndrome consists of what symptoms

Answer 27

WT Aniridia Genital anomalies Retardation

Question 28

Organomegaly, macroglossia, omphalocele

Answer 28

Beckwith wiedeman syndrome

Question 29

WT2 gene

Answer 29

Beckwith wiedeman syndrome

Question 30

Symptoms of Wilms tumor

Answer 30

Large abdominal mass Hematuria Abdominal pain Intestinal obstruction

Question 31

Wilms tumor triohasic pattern

Answer 31

Blastema Immature stroma Epithelial cells (tubules)