Drugs Exam 1

Question 0

Aspirin - function

Answer 0

Cox suicide inhibitor (no arachidonic acid to prostaglandin and thromboxane)

Question 1

Aspirin - structure

Answer 1

COO-

Question 2

Aspirin - body

Answer 2

Painkiller, anticoagulant

Question 3

Ibuprofen - structure

Answer 3

C=O
Ring
O’s

Question 4

Ibuprofen - function

Answer 4

Cox competitive inhibitor (stop arachidonic acid –> prostaglandin and thromboxane)

Question 5

Painkiller

Answer 5

.

Question 6

Organophosphates (sarin, DIFP) - structure

Answer 6

F-

CH3

Question 7

Organophosphates (sarin, DIFP) - function

Answer 7

Suicide inactivator of AChE

Question 8

Organophosphates (sarin, DIFP) - function

Answer 8

More ACh, death

Question 9

Atropine - function

Answer 9

Binds ACh receptor (buys more time to make AChE)

Question 10

Atropine - body

Answer 10

Treat organophosphate poisoning

Question 11

Pralidoxime - function

Answer 11

Reacts with pesticide so reactivates AChE

Question 12

Pralidoxime - body

Answer 12

Treat organophosphate poisoning

Question 13

PCN - structure

Answer 13

COO-
2 CH3
β-lactam ring

Question 14

PCN - function

Answer 14

Tricks cell wall transpeptidase into thinking it’s D-Ala-D-Ala

Question 15

PCN - body

Answer 15

ATB - inhibit bac cell wall synthesis

Question 16

Augmentin - structure (and parts)

Answer 16

Like PCN

Has amoxand clavulanate

Question 17

Augmentin - function

Answer 17

Tricks β-lactamase (produced by bacteria)

Question 18

Augmentin - body

Answer 18

ATB - fights ATB resistance to PCN

Question 19

Acyclovir - structure

Answer 19

Like G

Question 20

Acyclovir - function

Answer 20

Stop DNA synthesis

Question 21

Acyclovir - body

Answer 21

Treat HSV

Question 22

5-F-U - structure

Answer 22

Like dUMP except F instead of H

Question 23

5-F-U - function

Answer 23

Suicide thymidylate synthase (so no T for DNA synthesis)

Question 24

5-F-U - body

Answer 24

Chemotherapy

Question 25

Aminopterin & methotrexate - structure

Answer 25

Like DHF | COO-

Question 26

Aminopterin & methotrexate - function

Answer 26

Decrease cofactor recycling (so no T for DNA synthesis)

Question 27

Aminopterin & methotrexate - body

Answer 27

Chemotherapy

Question 28

81 ASA - structure

Answer 28

COO-

Question 29

81 ASA - function

Answer 29

COX inhibitor

Question 30

81 ASA - body

Answer 30

Anticoag

Question 31

Plavix - function

Answer 31

COX & ADP inhibitor

Question 32

Plavix - body

Answer 32

Anticoag

Question 33

Coumadin & dicoumarol - structure

Answer 33

Rings

Question 34

Coumadin & dicoumarol - function

Answer 34

Comp inhibitor of Vit KO reductase | Decrease gla domains

Question 35

Coumadin & dicoumarol - body

Answer 35

Prophylactic treatment of thromboembolic disorders

Question 36

Heparin & Lovenox - structure

Answer 36

SO3 2-

Question 37

Heparin & Lovenox - function

Answer 37

Increase AT3 action (which is a suicide inact of thrombin)

Question 38

Heparin & Lovenox - body

Answer 38

Anticoag (in anticoag step)

Question 39

tPA, urokinase, streptokinase - function

Answer 39

Convert plasminogen to plasmin, which cuts fibrin clot

Question 40

tPA, urokinase, streptokinase - body

Answer 40

Dissolution of fibrin clot after heart attack

Question 41

Botox - structure (overall)

Answer 41

Heavy chain, light chain

Question 42

Botox - function

Answer 42

Light chain is protease, cleaves docking proteins

Question 43

Botox - body

Answer 43

Cosmetic Treat dystonia Treat spasticity

Question 44

Curare - structure (like...)

Answer 44

ACh

Question 45

Curare - function

Answer 45

Competes with ACh at receptor (binds receptor so it's closed)

Question 46

Curare - body

Answer 46

Paralysis

Question 47

Succinylcholine - function

Answer 47

Binds ACh receptor to open it - causes depolarization

Question 48

Succinylcholine - body

Answer 48

Reversible muscle relaxation

Question 49

Tensilon - function

Answer 49

AChE inhibitor

Question 50

Tensilon - body

Answer 50

Build up more ACh, reversible

Question 51

Propranolol - function

Answer 51

Slight decrease expression of TGFβ

Question 52

Propranolol - body

Answer 52

Slight decrease aorta thickness and architecture

Question 53

Losartan - function

Answer 53

Decrease expression TGFβ

Question 54

Losartan - body

Answer 54

Decrease aorta wall thickness and architecture