4.29 2 Flashcards

(37 cards)

0
Q

Sotalol, Propafenone, other beta blocker ADRs

A

Bradycardia
Bronchospasm
Fatigue
Heart failure

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1
Q

Amiodarone ADRs

A

Hypo/hyperthyroidism
Pulmonary toxicity
Photosensitivity

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2
Q

Disopyramide ADRs

A

Anticholinergic symptoms

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3
Q

Procainamide ADRs

A

Lupus
Rash
Neutropenia

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4
Q

Lidocaine ADRs

A

CNS toxicity

  • delirium
  • stupor
  • confusion
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5
Q

Propafenone ADRs

A

Metallic taste

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6
Q

Hypo/hyperthyroidism ADR

A

Amiodarone

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7
Q

Pulmonary toxicity ADR

A

Amiodarone

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8
Q

Photo sensitivity ADR

A

Amiodarone

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9
Q

Bradycardia ADR

A

Sotalol, Propafenone, other beta blockers

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10
Q

Bronchospasm ADR

A

Sotalol, Propafenone, other beta blockers

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11
Q

Fatigue ADR

A

Sotalol, Propafenone, other beta blockers

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12
Q

Heart failure ADR

A

Sotalol, Propafenone, other beta blockers

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13
Q

Anticholinergic symptoms ADR

A

Disopyramide

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14
Q

Lupus ADR

A

Procainamide

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15
Q

Rash ADR

16
Q

Neutropenia ADR

17
Q

CNS toxicity (delirium, stupor, confusion) ADR

18
Q

Metallic taste ADR

19
Q

Renal elimination

A

Sotalol
Dofetilide
Digoxin

20
Q

Hepatic elimination

A

Propafenone
Amiodarone
Lidocaine

21
Q

Amiodarone drug interactions

A

Increases warfarin x2
Increases digoxin x2
Increases cyclosporine

Inhibit p gp (so incr verapamil and dig)
Inhibit 3A4 (statins)
22
Q

Dofetilide drug interactions

A

Increased by 3A4 inhibitors

Increases verapamil and digoxin by blocking P glycoprotein

23
Q

What drug increases warfarin x2

24
What drug increases digoxin x2
Amiodarone | Dofetilide?
25
What drug increases cyclosporine
Amiodarone
26
What drug is metabolized by 3A4
Dofetilide
27
What increases verapamil's levels
Dofetilide | Amiodarone
28
Pro arrhythmia more common in what classes of drugs
1A 1C III
29
Preferred drug for acute ventricular arrhythmias if pregnant
Lidocaine
30
What drugs are preferred for rate control in pregnancy
Digoxin and diltiazem
31
CI in pregnancy
Disopyramide (uterine contractions) Amiodarone (thyroid, bradycardia) Dronedarone (teratogen)
32
What drug inhibits 3A4
Amiodarone
33
What can not be used if also on statin
Amiodarone
34
What drug inhibits 2C9
Amiodarone
35
P glycoprotein breaks down
Verapamil | Digoxin
36
What drugs inhibit p glycoprotein secretion
Amiodarone | Dofetilide