9.27 Constipation and Diarrhea Meds

Question 1

aspiration causes pulmonary edema

Answer 1

polyethylene glycol (an osmotic laxative)

Question 2

causes melanosis coli

Answer 2

anthraquinones (a non specific irritant)

Question 3

irritated throat

Answer 3

ducosate sodium (stool softener)

Question 4

causes anal seepage

Answer 4

mineral oils (an emollient)

Question 5

lipoid pneumonia if aspirated

Answer 5

mienral oils (an emollient)

Question 6

decreases absorption of fat soluble vitamins

Answer 6

mineral oils (emollient)

Question 7

causes rectal mucosal damage and hyperphosphatemia

Answer 7

soapsuds (enema)

Question 8

activates type 2 chloride channels

Answer 8

lubiprostone (chloride channel activator)

Question 9

analog of heat stable enterotoxins and acts on guanylyl cyclase

Answer 9

linaclotide (chloride channel activator)

Question 10

4 things in WHO oral rehydration solution

Answer 10

NaCl

KCl

glucose or sucrose

trisodium citrate or sodium bicarb

Question 11

antibiotics for diarrhea if high infection

Answer 11

fluoroquinolones or rifaximin

Question 12

used in bile salt induced diarrhea (if resected distal ileum)

Answer 12

cholestyramine, colesevelam, colestipol (bile acid binding agents)

Question 13

opiate with low CNS penetration

Answer 13

loperamide

Question 14

opiates that need atropine added

Answer 14

diphenoxylate

difenoxin

Question 15

difenoxin MOA

Answer 15

mu opioid receptor agonist (decr motility)

Question 16

piperidine derivative

Answer 16

loperamide, diphenoxylate, difenoxin

Question 17

for travelers diarrhea

Answer 17

loperamide