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Psych 2 Flashcards

(53 cards)

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0
Q

Namenda

A

NMDA receptor antagonist

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1
Q

Most abundant amino acid in CNS

A

Glutamate

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2
Q

Lamotrigine

A

Inhibits release of glutamate

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3
Q

Gabapentin

A

Decreases production of glutamate

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4
Q

Valproate

A

Anticonvulsant

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5
Q

Clinical uses for glutamate

A

Anti seizure
Bipolar
Chronic pain

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6
Q

Clinical uses for GABA

A

Seizure
Anxiety
Quiet high

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7
Q

2 drugs that bind GABA A receptor

A

Benzodiazepines

Barbiturates

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8
Q

Drug that opens GABA A more frequently

A

Benzodiazepines

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9
Q

Drug that opens GABA A more widely

A

Barbiturates

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10
Q

Dopamine’s 5 main roles

A 
Mood
Psychosis
PD
Fear
Drug addiction
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11
Q

Neurotransmitter change in depression

A

Decrease dopamine in left prefrontal cortex

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12
Q

Neurotransmitter change in psychosis

A

Increase dopamine in striatum

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13
Q

Receptor changes in schizophrenia

A

Decrease D1 in DLPFC

Increase D2 in striatum

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14
Q

Most dopamine neurons arise in

A

Substantia nigra

Ventral tegmental area

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15
Q

4 dopamine tracts

A

Nigrostriatal
Tuberoinfundibular
Mesolimbic
Mesocortical

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16
Q

Regulation of muscle tone in what dopamine tract

A

Nigrostriatal

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17
Q

Parkinson’s motor symptoms is lack of dopamine in what tract

A

Nigrostriatal

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18
Q

Can see Parkinson’s like movement when people take

A

Antipsychotics (block dopamine in nigrostriatal)

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19
Q

Dopamine inhibits prolactin in what tract

A

Tuberoinfundibular

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20
Q

Positive symptoms of schizophrenia (hallucinations) associated with

A

Mesolimbic excess of dopamine

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21
Q

Negative symptoms of schizophrenia (apathy) due to

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A

Dopamine deficit in Mesocortical pathway

22
Q

Mesolimbic pneumonic

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A

Cranky
Crazy
Craving

23
Q

Mesocortical tract pneumonic

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A

Feeling
Focus
Full stop

24
NE is synthesized from
Dopamine
25
NE arises from what brain structure
Locus ceruleus
26
2 mood drugs
NE | 5HT
27
Serotonin originates from what brain structure
Raphe nucleus
28
Estrogen promotes what neurotransmitter
Serotonin
29
Activation of which receptors cause hallucinogenic activity of LSD?
5HT2a
30
Blocking 5HT3 receptor causes
Decrease in nausea (if in area postrema)
31
Blocking 5HT2c causes
Increase in NE and 5HT in PFC
32
NE in amygdala causes
Fear and anxiety
33
5HT in amygdala causes
Calm
34
NE in OFC causes
Mood lift
35
5HT in OFC causes
Decrease in OCD bx
36
Low serotonin causes
Depression and anxiety
37
Too much serotonin causes
Psychosis and euphoria
38
ACh is clinically relevant in what disease
Alzheimer's
39
ACh is in what brain structure
Nucleus basalis of Meynert
40
ACh made from
Acetyl coa | Choline
41
2 enzymes that remove ACh from synapse
Acetylcholinesterase | Butyrlcholinesterase
42
Butyrlcholinesterase is secreted from
Glial cells
43
ACh receptor types
Muscarinic (more abundant) | Nicotinic
44
Dry mouth, blurred vision, constipation, urinary hesitancy caused by
Blocked ACh muscarinic receptor
45
Delirium is caused by
Not enough ACh
46
Histamine released from what brain structure
Hypothalamus
47
Histamine uses
Allergy relief | Sedation
48
Depression neurotransmitters
Low serotonin Low dopamine Low NE
49
Mania
Too much dopamine
50
Psychosis neurotransmitters
Too much dopamine Too much serotonin Too much glutamate
51
Anxiety neurotransmitters
Low serotonin Low GABA Too much NE
52
Dementia neurotransmitters
Low ACh | Too much glutamate

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