6.22 Gout Drugs

Question 1

What enzyme is used to make uric acid

Answer 1

Xanthine oxidase

Question 2

Drugs for acute gout

Answer 2

NSAIDS
Glucocorticoids
Colchicine

Question 3

What med should you avoid for acute gout

Answer 3

aspirin (decreases renal uric acid excretion)

Question 4

Gout flares are treated / prophylaxis w/

Answer 4

NSAID

Colchicine

Question 5

Chronic gout treatment

Answer 5

Xanthine oxidase inhibitor
Colchicine
Uricosuric
Pegloticase for treatment resistant gout

Question 6

Inhibits xanthine oxidase

Answer 6

Allopurinol

Febuxostat

Question 7

Discontinue if have rash

Answer 7

Allopurinol

Question 8

Uricosuric drugs increase excretion of

Answer 8

Allopurinol

Febuxostat

Question 9

Faster and more effective than allopurinol at reducing serum uric acid

Answer 9

Febuxostat

Question 10

Increases cardiovascular events (MI, stroke) and deaths

Answer 10

Febuxostat

Question 11

Given IV

Answer 11

Pegloticase

Question 12

Recombinant uricase enzyme

Answer 12

Pegloticase

Question 13

Peglated

Answer 13

Pegloticase

Question 14

Breaks down uric acid to allantoin

Answer 14

Pegloticase

Question 15

Allergic reaction in 25% of paitents

Answer 15

Pegloticase

Question 16

What is used to prevent allergic reaction to pegloticase

Answer 16

Antihistamine and glucocorticoids

Question 17

Antibody formation to drug

Answer 17

Pegloticase

Question 18

Inhibits microtubule formation

Answer 18

Colchicine

Question 19

Inhibits mitosis of rapidly dividing cells

Answer 19

Colchicine

Question 20

Inhibits chemotaxis and secretion of inflammatory mediators

Answer 20

Colchicine

Question 21

Alopecia

Answer 21

Colchicine

Question 22

Bone marrow suppression

Answer 22

Colchicine

Question 23

Myopathy

Answer 23

Colchicine

Question 24

Renal toxicity

Answer 24

Colchicine

Question 25

Uricosuric agents

Answer 25

Probenecid | Sulfinpyrazone

Question 26

Eliminates uric acid

Answer 26

Uricosuric agents - Probenecid - Sulfinpyrazone

Question 27

Decrease net reabsorption of uric acid in proximal tubule

Answer 27

Uricosuric agents - Probenecid - Sulfinpyrazone

Question 28

Causes kidney stones

Answer 28

Uricosuric agents - Probenecid - Sulfinpyrazone

Question 29

Cytopenias

Answer 29

Sulfinpyrazone

Question 30

Decreases renal secretion of organic acids (PCN, NSAIDs)

Answer 30

Probenecid

Question 31

Salicylates decrease effectiveness of

Answer 31

Uricosuric agents - Probenecid - Sulfinpyrazone

Question 32

Gout diet limits

Answer 32

Meat, poultry, fish Saturated fat (decr UA elim) Alcohol (decr UA elim) HFCS (incr UA)