4.16 pharm HTN Flashcards

(73 cards)

0
Q

Not used for mono therapy

A

Alpha blockers

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1
Q

Meds not useful for Af am and elderly

A

Beta blockers

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2
Q

May be used for add on therapy for BPH

A

Alpha blockers

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3
Q

Central acting sympathomimetic that’s safe for pregnancy

A

Methyldopa

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4
Q

More effective than thiazides if have moderate or severe renal insufficiency

A

Loop diuretics (Torsemide, furosemide)

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5
Q

Used in combo with thiazides to decrease hypokalamia risk

A

ENaC inhibitor and aldosterone antag

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6
Q

Direct Vasodilators for HTN

A

Hydralazine

Minoxidil

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7
Q

What causes hypertrichosis

A

Minoxidil

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8
Q

What causes lupus like syndrome

A

Hydralazine

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9
Q

Direct vasodilator that can be used in pregnancy

A

Hydralazine

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10
Q

If combo with nitrates, effective for CHF

A

Hydralazine

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11
Q

Vasodilators for hypertensive emergencies

A

Labetalol
Clevidipine
Nitroprusside
Fenoldopam

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12
Q

DHP CCB with short half life used for hypertensive emergencies

A

Clevidipine

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13
Q

Releases cyanide

A

Nitroprusside

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14
Q

Contraindicated in people with glaucoma

A

Fenoldopam

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15
Q

If have hypertensive emergency an renal impairment

A

Fenoldopam

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16
Q

Dopamine D1 agonist

A

Fenoldopam

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17
Q

Anti hypertensives for pregnant

A

Methyl dopa
Labetalol
Nifedipine
Hydralazine

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18
Q

What med for pre eclampsia

A

Hydralazine

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19
Q

What are CI in pregnancy

A

ACEI
ARB
Renin inhibitor
Nitroprusside

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20
Q

Activates reflexes

A
Thiazide
Long acting DHPs
Beta blockers
Alpha blockers
Direct vasodilators
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21
Q

Not used if coronary artery disease because can cause MI

A

Direct Vasodilators

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22
Q

If prescribe vasodilator, also should prescribe

A
Beta blocker (counteract reflex tach)
Diuretic (counteract fluid retention)
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23
Q

Opens K channels in arterioles as MOA

A

Minoxidil

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24
ADR hyperuricemia
Thiazide diuretics
25
ADR hypokalemia
Thiazide diuretics
26
ADR metabolic acidosis
Thiazide diuretics | Nitroprusside
27
ADR Hyponatremia
Thiazide diuretics
28
ADR Increase LDL, total chol, TGs
Thiazide diuretics
29
ADR Hyperglycemia / impaired glucose tolerance / decrease insulin secretion
Thiazide diuretics
30
ADR ED
Thiazide diuretics
31
ADR severe hypotension
ACE inhibitors ARBs Fenoldopam (just hypotension)
32
ADR hyperkalemia
ACE inhibitors | ARBs
33
ADR acute renal failure with bilateral renal artery stenosis
ACE inhibitors | ARBs
34
Heart failure comorbidity
ACE inhibitors Beta blockers Aldosterone antagonist BiDil (Hydralazine plus nitrate)
35
Post MI comorbidity
ACE inhibitor | Beta blockers
36
Maintains renal function / renoprotective
ACE inhibitors | ARBs
37
A fib comorbidity
Verapamil | Diltiazem
38
Angina comorbidity
Verapamil Diltiazem Beta blockers
39
ADR fatigue
Beta blockers
40
ADR exercise intolerance
Beta blockers
41
ADR sedation
Central acting sympathomimetics (Clonidine, methyl dopa)
42
Helpful to add to 2 or 3 drug regiment in resistant HTN
Aldosterone antag
43
High variable first pass metabolism via acetylation
Hydralazine
44
Used for isolated systolic HTN
Long acting DHPs
45
Flat dose response curve
ACE inhibitors | ARBs
46
Which beta blockers are used for HTN
Cardio selective (beta 1) Metoprolol Acebutolol Esmolol
47
Converted to alpha methyl norepinephrine
Methyldopa
48
Converted to alpha methyl norepinephrine
Methyldopa
49
Used with beta blocker and diuretic
Direct Vasodilators (Hydralazine, minoxidil)
50
Used with beta blocker and diuretic
Direct Vasodilators (Hydralazine, minoxidil)
51
ADR fluid retention /edema
Direct Vasodilators (Hydralazine, minoxidil)
52
ADR fluid retention /edema
Direct Vasodilators (Hydralazine, minoxidil)
53
ADR angina/MI/arrhythmia
Direct vasodilator (Hydralazine, minoxidil)
54
ADR angina/MI/arrhythmia
Direct vasodilator (Hydralazine, minoxidil)
55
ADR sweating
Direct vasodilator (Hydralazine, minoxidil)
56
ADR sweating
Direct vasodilator (Hydralazine, minoxidil)
57
Minoxidil has which ADRs more than Hydralazine
Reflex tach | Edema
58
Minoxidil has which ADRs more than Hydralazine
Reflex tach | Edema
59
Dilates mesenteric and cerebral arteries
Fenoldopam
60
Dilates mesenteric and cerebral arteries
Fenoldopam
61
Dilates kidney arteries, causing natures is, diuresis, kaliuresis
Fenoldopam
62
Dilates kidney arteries, causing natures is, diuresis, kaliuresis
Fenoldopam
63
Activates guanylyl cyclase
Nitroprusside
64
Activates guanylyl cyclase
Nitroprusside
65
Given if hypertensive emergency and severe heart failure
Nitroprusside
66
Given if hypertensive emergency and severe heart failure
Nitroprusside
67
ADR muscle weakness
Nitroprusside
68
ADR muscle weakness
Nitroprusside
69
Other Vasodilators for hypertensive urgency
Diazoxide Esmolol Enaliprilat
70
Other Vasodilators for hypertensive urgency
Diazoxide Esmolol Enaliprilat
71
Most effective in conditions associated with high plasm renin level
ACE inhibitors
72
Nitroprusside ADRs (metabolic acidosis, muscle weakness, spasm, confusion, seizures) more common in what people
Renal impairment / impaired metabolism