Perrotta Flashcards by Lu Chen

diseases associated with ovalocytes

hereditary ovalocytosis

iron deficiency

thalassemia

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diseases associated with spherocytes

hereditary spherocytosis

WAHA

cold agglutinate disease

paroxysmal cold hemoglobinuria

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pelger huet cells associated w/

myelodysplastic syndromes

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erythropoiesis occurs in what organs

yolk sac

liver

spleen

bone marrow

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extramedullar hematopoiesis organs

spelen

liver

lymph nodes

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heme is made up of

1 Fe2+ and porphyrin ring

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low to normal MCV with high MCHC

hereditary spherocytosis

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defects in alpha spectrin cause

hereditary elliptocytosis

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severe form of hereditary elliptocytosis is called

pyropoikilocytosis

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defect in ankyrin

hereditary spherocytosis

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target cells are present in

Hb SC

thalassemia (esp beta)

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increased RDW (anisocytosis)

iron def anemias

macrocytic anemias

hemolytic anemias

(most anemias)

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most common mutation in beta thal

point mutation

splicing mutation for beta+
chain terminator mutations for beta 0

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Cooley’s anemia same as

beta thal major

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crewcut appearance

beta thal major

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tx for beta thal major

blood transfusions

BMT

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dx PNH

flow cytometry

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treat PNH

BMT

growth factors

anti-complement Ab (eculizumab)

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treat WAHA

1st line: steroids

splenectomy

Rituximab

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mechanism of alpha methyldopa causing WAHA

autoantibody (IgG)

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mechanism of penicillin causing WAHA

IgG against drug/membrane complex “happen” mechanism

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mechanism of cephalosporins causing WAHA

IgG against drug/membrane complex “happen” mechanism

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mechanism of quinidine causing WAHA

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“immune complex” / “ternary complex” IgM formed

drug related WAHA: positive for

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Coombs test

what test for paroxysmal cold hemoglobinuria

Donath-Landsteiner test (IgG anti- P Ab binds at low temp and complement lyses at higher temp)

causes of ineffective erythropoiesis

B12 and folate deficiency thalassemia myelodysplastic syndrome iron overload

pernicious anemia has increased risk of what cancer

gastric cancer (so do endoscopy)

what disease causes degeneration of myelin in dorsal and lateral tracts "subacute combined degeneration"

pernicious anemia

test to distinguish pernicious anemia vs other causes of B12 deficiency

Schilling test

after start rx for folate deficiency, should see what in blood

reticulocytosis

TIBC equation

TIBC = transferrin x 1.4

transferrin saturation equation

transferrin saturation = Fe / TIBC

acute phase reactant

ferritin

2 effects of increased hepcidin

decreased iron form macrophages to erythroid precursors suppress EPO

what is Fanconi's anemia

rare autosomal recessive disorder in proteins required for DNA repair

pathophys of aplastic anemia

damaged stem cell expresses a new antigen, which causes T cell to attack it damaged stem cell can't proliferate normally

treatment for aplastic anemia (child and adult)

child: BMT adult: antithymocyte globulin and cyclosporine

pure red cell aplasia can be secondary to

parvovirus B19 thymoma

chronic kidney failure causes what type of anemia

normocytic, normochromic

most common infectious cause of acute chest syndrome in sickle cell disease

Chlamydia pneumoniae

best screening test for pulmonary artery hypertension in SCD

echo for tricuspid regurg jet velocity

treatment goal of stroke in SCD

reduce HbS percentage

biggest indication for chronic transfusion in SCD

stroke prevention

autoantibody that recognizes platelet surface glycoproteins (GPIIb/IIa, etc) and platelets removed by macrophages

immune thrombocytopenic purpura

first line treatment for chronic ITP

corticosteroids IVIG WinRho

HPA-1a antibody

neonatal alloimmune thrombocytopenia

treatment for NAT

IVIG maybe corticosteroids maybe plt transfusion from mom

tx for HIT

direct thrombin inhibitors

serotonin release assay tests for

HIT

reversal of coumadin

fresh frozen plasma

use fresh frozen plasma for

reversal of coumadin liver disease DIC massive transfusion TTP

liver disease causes decreased synthesis of

vit K cep factors (2,7,9,10, C, S) antiplasmin (so increased fibrinolysis)

treatments for vWD

DDAVP vWF anti fibrinolytics

cryoprecipitate is used in

hypofibrinogenemia uremic bleeding

what is used to guide FFP transfusion

PT and PTT

transfusion related graft vs host disease is mediated by which lymphocyte

T lymphocyte

Perrotta Flashcards

(56 cards)