3.12 neoplasm

Question 0

What virus makes E6 and E7 proteins

Answer 0

HPV

Question 1

EBV causes

Answer 1

Burkitt lymphoma
B cell lymphomas
Hodgkin lymphomas
Nasopharyngeal carcinoma
T/NK cell lymphomas

Question 2

What does E6 protein do

Answer 2

Degrades p53 and BAX

Question 3

What does E7 do

Answer 3

Binds RB which allows release of E2F and promotion of cell cycle

Inactivated CDKIs: p21 and p27

Question 4

Mechanism of EBV

Answer 4

LMP-1 activates NFκB and induces pro-angiogenic factors

Question 5

What has a starry sky histo

Answer 5

Burkitt lymphoma

Question 6

H pylori causes

Answer 6

Gastric adenocarcinomas

MALTomas

Question 7

H pylori mechanism

Answer 7

H pylori’s CagA activates SHP-2 tyrosine kinase

Question 8

Aflatoxin B1 produces mutation in what gene

Answer 8

TP53

Question 9

Benzo[a]pyrene causes what cancer

Answer 9

Scrotal skin cancer

Question 10

Benzo[a]pyrene is metabolized by

Answer 10

CYP1A1

Question 11

Ionizing radiation causes what cancers

Answer 11

Leukemia
Thyroid
Breast
Lung
Salivary glands

Question 12

HTLV carries what gene which does what

Answer 12

Tax gene - inactivated cell cycle inhibitor p16/INK4a

Question 13

What virus has environmental factors as well such as smoking, dietary deficiencies, etc

Answer 13

HPV