4.15 pharm CHF Flashcards
(22 cards)
Phosphodiesterase inhibitors / inodilators
Imarinone
Milrinone
Cardiac glycosides
Digoxin
Digitoxin
Ouabain
Alpha 1 adrenoreceptor antagonist
Prazosin
Adrenoreceptor agonists
Dopamine
Dobutamine
Used for stage D CHF
Digoxin Digitoxin Ouabain Imarinone Milrinone Dopamine Dobutamine Nesirtide
Mechanism of cardiac glycosides
Block Na/K which increases Ca in myocytes via NCX which increases CO
Cardiac glycosides interchangeable with
Digitalis
What med for CHF also can be used as an anti arrhythmic
Digoxin
Digitoxin
Ouabain
What can increase mortality when administered chronically
Imarinone
Milrinone
What is used specifically for acute heart failure
Imarinone
Milrinone
Mechanism of Imarinone and milrinone
Inhibit cAMP phosphodiesterase III so increases cAMP which increases contractility
In periphery, vasodilation so decrease afterload
CI in severe CHF due to decreased inotropic effects
Metoprolol
Bisoprolol
Arterial vasodilator
Hydralazine
Venous dilator
Organic nitrates
Dilate arterial and venous
Sodium nitroprusside
BiDil
What is BiDil made out of
Isosorbide dinitrate
Hydralazine
Diuretic classes for CHF
Thiazides
Loop diuretics
Aldosterone antagonists
Med that causes natriuresis and diuresis
Nesirtide
Nesirtide is actually
Human B type natriuretic peptide
May cause arrhythmias due to increased cAMP
Imarinone
Milrinone
BiDil is used for Af am less responsive to
ACE inhibitors
Spares heart from baroreceptor reflex
Prazosin
