Antimycobacterial drugs

Question 0

Activated by KatG (catalase peroxidase)

Answer 0

Isoniazid

Question 1

First line drugs that are also prodrugs

Answer 1

Isoniazid

Pyrazinamide

Question 2

Inhibits DNA dependent RNA polymerase

Answer 2

Rifampin

Question 3

Active drug of isoniazid

Answer 3

Nicotinoyl radical or isoniazid

Question 4

What does activated isoniazid do

Answer 4

Inhibits InhA and KasA which are used in synthetic pathway of mycolic acids

Question 5

Used for continuation phase of TB only

Answer 5

Rifapentin

Question 6

Inhibits arabinogalatan pathway

Answer 6

Ethambutol

Question 7

Inhibits 30S

Answer 7

Streptomycin

Question 8

First line drug that can also be used for other bacteria

Answer 8

Rifampin

Question 9

Most hepatotoxic

Answer 9

Pyrazinamide

Question 10

Increases LFTs

Answer 10

Isoniazid
Rifampin
Pyrazinamide

Question 11

An alcoholic may be most problematic with which drug

Answer 11

Isoniazid

Question 12

Isoniazid Hepatotoxicity worst in what populations

Answer 12

Pregnant
Post partum
Alcoholic
HIV

Question 13

Slow acetylators problematic in

Answer 13

Isoniazid

Question 14

CYP 2E1 most problematic if taking

Answer 14

Isoniazid

Question 15

Isoniazid may be problematic with inducers of CYP

Answer 15

2E1

Question 16

If you prescribe isoniazid, should also prescribe

Answer 16

Pyridoxine (B6)

Question 17

Pyridoxine prescribed with

Answer 17

Isoniazid

Question 18

Neurotoxicity most often in people taking isoniazid and are also

Answer 18

Slow acetylators

Question 19

Turns bodily secretions red orange

Answer 19

Rifampin

Question 20

Thrombocytopenia at high doses

Answer 20

Rifampin

Question 21

Renal hypersensitivity reactions (nephritis, tubular necrosis)

Answer 21

Rifampin

Question 22

Can cause visual symptoms (pain, blurred vision)

Answer 22

Rifabutin

Question 23

Can cause hepatitis

Answer 23

Pyrazinamide

Question 24

Can precipitate gout attacks

Answer 24

Pyrazinamide | Ethambutol

Question 25

Can cause non gouty arthralgias

Answer 25

Pyrazinamide

Question 26

Can cause optic neuritis

Answer 26

Ethambutol

Question 27

Can cause decrease visual acuity

Answer 27

Ethambutol

Question 28

Can cause red green color blindness

Answer 28

Ethambutol

Question 29

Can cause ototoxicity, primarily vestibular

Answer 29

Streptomycin

Question 30

What can mask ototoxicity of streptomycin

Answer 30

Antihistamine

Question 31

Avoid in pregnancy (category D)

Answer 31

Streptomycin

Question 32

Nephrotoxicity

Answer 32

Streptomycin | Rifampin

Question 33

Isoniazid resistance

Answer 33

Mutation/deletion of KatG Overexpress InhA Increased resistance to oxidative stress

Question 34

Need to limit tyramine due to MAOI effects

Answer 34

Isoniazid

Question 35

Can cause serotonin syndrome

Answer 35

Isoniazid

Question 36

Inhibitor of 3A4 and 2C19

Answer 36

Isoniazid

Question 37

Isoniazid CYP interactions

Answer 37

Inducer of 2E1 | Inhibitor of 3A4 and 2C19

Question 38

Rifampin resistance

Answer 38

Mutation in RNA polymerase

Question 39

Rifampin CYP interactions

Answer 39

Strong inducer of 3A4 and others

Question 40

What interacts with oral contraceptives

Answer 40

Rifampin

Question 41

What interacts with warfarin

Answer 41

Rifampin

Question 42

What interacts with HIV drugs

Answer 42

Rifampin

Question 43

Least amount of CYP 3A4 induction of rifampins

Answer 43

Rifabutin

Question 44

Pyrazinamide resistance

Answer 44

Mutation in pyrazinamidase (enzyme that activates pyrazinamide)

Question 45

Renal elimination

Answer 45

Pyrazinamide Ethambutol Streptomycin

Question 46

Clearance and Vd larger for males and larger mass

Answer 46

Pyrazinamide

Question 47

Ethambutol resistance

Answer 47

Mutation in arabinosyl transferase

Question 48

Streptomycin resistance

Answer 48

Mutations in ribosomal RNA and proteins

Question 49

Bactericidal to rapidly dividing extra cellular and bacteristatic to slowly dividing (intercellular and cavities)

Answer 49

Isoniazid

Question 50

Hepatic acetylation of isoniazid by

Answer 50

NAT2

Question 51

Hepatotoxic isoniazid metabolite

Answer 51

Hydrazine

Question 52

Bactericidal everywhere

Answer 52

Rifampin

Question 53

Deacetylated in the liver

Answer 53

Rifampin

Question 54

Bactericidal to cells in macrophages and edge of cavities

Answer 54

Pyrazinamide

Question 55

Inhibits only rapidly growing extra cellular

Answer 55

Ethambutol | Streptomycin

Question 56

Weakest of 1st line drugs

Answer 56

Ethambutol

Question 57

Inhibits ATP synthase of mycobacterium

Answer 57

Bedaquiline

Question 58

For MDR-TB only

Answer 58

Bedaquilline | Aminosalicylic acid

Question 59

Inhibits thymine nucleotide synthesis

Answer 59

Aminosalicylic acid

Question 60

Second line prodrug

Answer 60

Ethionamide

Question 61

Inhibits InhA

Answer 61

Ethionamide

Question 62

Inhibits peptidoglycan synthesis

Answer 62

Cycloserine

Question 63

Can cause seizures

Answer 63

Cycloserine

Question 64

Use pyridoxine for what second line drug

Answer 64

Cycloserine

Question 65

Second line drug renal elim

Answer 65

Cycloserine

Question 66

CI in psych disease

Answer 66

Cycloserine

Question 67

CI in renal impaired

Answer 67

Cycloserine

Question 68

CI in epilepsy

Answer 68

Cycloserine

Question 69

Can cause severe GI upset

Answer 69

Ethionamide | Aminosalicylic acid

Question 70

CNS toxicity second line (depression, sensory disturbances)

Answer 70

Ethionamide

Question 71

Highly plasma protein bound

Answer 71

Bedaquilline

Question 72

QT prolongation

Answer 72

Bedaquilline

Question 73

Increase risk of death

Answer 73

Bedaquilline

Question 74

Increase LFTs second line

Answer 74

Bedaquilline

Question 75

Headache and arthralgias

Answer 75

Bedaquilline

Question 76

Anti leprosy drugs

Answer 76

Rifampin | Dapsone

Question 77

Inhibits folate synthesis

Answer 77

Dapsone

Question 78

Inhibits neutrophils

Answer 78

Dapsone

Question 79

Antioxidant

Answer 79

Dapsone

Question 80

Hemolysis esp in G6DP deficiency

Answer 80

Dapsone

Question 81

Methemoglobinemia ADR

Answer 81

Dapsone

Question 82

Drugs for M avium complex

Answer 82

Rifampin Ethambutol Clarithromycin or azithromycin

Question 83

Second line drug that causes hepatitis

Answer 83

Ethionamide

Question 84

Second line drug useful for intracellular and extracellular but not in cavities

Answer 84

Quinolones