6.2 Sedative-Hypnotics Flashcards by Lu Chen

Q

phenobarbital

A

long acting barbiturate

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Q

barbiturate for treatment of seizures

A

phenobarbital

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Q

primidone

A

long acting barbiturate

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Q

amobarbital

A

intermediate acting barbiturate

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Q

pentobarbital

A

short acting barbiturate

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Q

secobarbital

A

short acting barbiturate

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Q

thiopental

A

ultra short acting barbiturate

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Q

flurazepam

A

long acting benzo

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Q

lorazepam

A

intermediate/short acting benzo

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Q

temazepam

A

intermediate/short acting benzo

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Q

triazolam

A

shortest acting benzo

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Q

midazolam

A

short acting benzo

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Q

flumazenil

A

BDZ antagonist for overdose of benzo

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Q

treat benzo overdose

A

flumazenil

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Q

barbiturate for induction of anesthesia

A

thiopental

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Q

flurazepam metabolized to

A

desalkyl-flurazepam

desmethyldiazepam

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Q

tolerance in benzos develops to

A

sleep-inducing effects (not anxiety decreasing effects or respiratory depression)

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Q

benzo CI in pregnancy

A

temazepam

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Q

for moderate insomnia in presence of anxiey

A

lorazepam

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Q

severe insomnia

A

temazepam

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Q

acute insomnia (jet lag)

Study These Flashcards

A

triazolam

Q

benzo for anesthesia & anterograde amnesia

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A

midazolam

Q

flumazenil CI

Study These Flashcards

A

patients with hx of seizures
barbiturate overdose
TCA overdose

Q

benzo withdrawal

Study These Flashcards

A

tremors
rebound REM
formication
hallucinations

Z drug mechanism

binds to alpha 1 GABAA receptor

benefit of Z drug over benzo

little effect on sleep cycle / REM sleep

must use lower dose of Z drugs in what patients

elderly and liver disease (b/c liver metabolism)

only sedative that can be used long term

eszopiclone

eszopiclone levels can be increased by

inhibitors of CYP 3A4 and 2E1

psychomotor impairment

eszopiclone

memory impairment

eszopiclone | zolpidem

visual hallucinations when combined w/ SSRIs

zolpidem

rebound insomnia at high doses

zaleplon

shortest duration Z drug

zaleplon

orexin receptor antagonist

suvorexant

non-scheduled prescription drug for insomnia

ramelteon

similar MOA as melatonin

ramelteon

MT1 and MT2 receptor antagonist

ramelteon

ramelteon MOA

MT1 and MT2 receptor antagonist

diphenhydramine

antihistamine

doxylamine

antihistamine

chlorpheniramine

antihistamine

serotonin derivative neuroendocrine

melatonin

south pacific island plant

kava kava

herbal that is metabolized to desmetyldiazepam

valerian root

all sedative hypnotics CI in people with

obstructive sleep apnea

treatment for restless leg syndrome

ropinirole pramipexol

ropinirole MOA

D2 receptor agonist

pramipexol MOA

D2 receptor agonist

NT of restless leg syndrome

lacks dopamine

restless leg syndrome is like what psych disorder

parkinson's