4.4 pharm Flashcards by Lu Chen

Q

How is normetanephrine made

A

Norepinephrine metabolized by COMT

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Q

How is metanephrine made

A

Epinephrine metabolized by COMT

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Q

Pathology of pheochromocytoma

A

Increased epinephrine (which increases BP and VMA in urine)

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Q

Homovanillic acid is made from

A

Dopamine

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Q

Can treat pheochromocytoma

A

α methyltyrosine

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Q

Is a more potent α2 agonist than NE

A

Methyl dopa (which gets converted to methyl-NE)

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Q

Makes a false NE

A

Methyl-dopa

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Q

Blocks NET

A

Cocaine

TCAs

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Q

Blocks VMAT

A

Reserpine

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Q

Strong CNS depressant

A

Reserpine

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Q

Causes a tachyphylactic response

A

MAOI

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Q

Indirect acting sympathomimetic

A

MAOI

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Q

Can’t eat food high in tyramine (veer, wine, cheese)

A

MAOI

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Q

NE local anesthetic effect

A

Bretylium

Guanethidine

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Q

Example of COMT inhibitor

A

Talcapone

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Q

Inhibits extra neuronal uptake

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A

Glucocorticoids

Q

Treats Parkinson’s

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A

COMT inhibitors (talcapone)