2.5 immuno

Question 0

Described by clinical disease is type

Answer 0

II

Question 1

Immediate hypersensitivity is type

Answer 1

I

Question 2

Serum sickness is type

Answer 2

III

Question 3

Arthus reaction is type

Answer 3

III

Question 4

Delayed type hypersensitivity is type

Answer 4

IV

Question 5

IgE mediated hypersensitivity is type

Answer 5

I

Question 6

Non IgE / antibody mediated hypersensitivity is type

Answer 6

II

Question 7

Immune complex disease is type

Answer 7

III

Question 8

T cell mediated hypersensitivity is type

Answer 8

IV

Question 9

Immune complex disease uses what immunoglobulin

Answer 9

IgG

Question 10

Type III hypersensitivity uses

Answer 10

IgG

Question 11

Why is hypersensitivity latent period so long?

Answer 11

IgE bound to mast cell decreases mast cell turnover

Question 12

Initial sensitization pathway

Answer 12

Allergen recognized by APC
APC presents antigen to cd4 T cell (Th)
Th releases IL4
IL4 binds B cell 
B cell releases IgE

Question 13

Examples of spasmogens

Answer 13

Histamine
PGD2
LTC4, LTD4

Question 14

What do spasmogens do

Answer 14

Bronchial smooth muscle contraction
Mucosal edema
Mucous secretion

Question 15

What causes bronchial smooth muscle contraction

Answer 15

Histamine
PGD2
LTC4, LTD4

Question 16

Creation of microthrombi due to release of

Answer 16

Platelet activating factor (PAF)

Question 17

What activates C3 to make C3a and C5a

Answer 17

Tryptase

Question 18

What are the activators

Answer 18

Histamine
PAF
Tryptase

Question 19

What causes vasodilation and edema

Answer 19

Kininogenase which becomes kinin

Question 20

What molecules lead to blood leaving vessels and then hypovolemic shock

Answer 20

Histamine

Kininogenase

Question 21

A benefit of IgE reactions

Answer 21

IgE mediates release of things from eosinophils that are toxic to parasites

Question 22

Hemolytic anemia of newborn is a type

Answer 22

II

Question 23

How to prevent hemolytic anemia of newborn

Answer 23

Give mom anti Rh IgG

Question 24

SLE is an example of type

Answer 24

III

Question 25

Type of hypersensitivity reaction occurring after vaccination

Answer 25

Arthus reaction (type III)

Question 26

What happens in an Arthus reaction

Answer 26

Injected antigen activates immune complex Immune complex activates complement C5a binds to C5a receptor on mast cell Immune complex binds to FCgRIII on mast cell to induce degranulation Local inflammation, fluid and protein release, phagocytosis, blood vessel occlusion

Question 27

If you give a patient monoclonal Ab, streptokinase, or drugs like PCN, might

Answer 27

Get serum sickness

Question 28

Serum sickness causes

Answer 28

Fever Vasculitis Arthritis Nephritis Because immune complexes deposit in small vessels

Question 29

Contact hypersensitivity is a type

Answer 29

IV

Question 30

Mechanism of type IV hypersensitivity

Answer 30

Ag in subcutaneous tissue and processed by APC A Th1 effector cell recognized antigen (APC stimulates Th1) and releases cytokines that activate vascular endothelium Recruit T cells, phagocytes, fluid, protein

Question 31

Poison ivy is a type

Answer 31

IV