7.12 Anticoags Flashcards by Lu Chen

Q

antidote of unfractionated heparin

A

protamine

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Q

only heparin that can’t use protamine as antidote

A

fondaparinux

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Q

warfarin inhibits

A

vitamin K epoxide reductase

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Q

phytonadione

A

treats warfarin overdose (is vitamin K)

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Q

inhibits platelet PDE

A

dipyridamole

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Q

metabolized by 2C19, but ok to use with PPIs (doesn’t cause problems)

A

clopidogrel

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Q

abciximab mechanism

A

monoclonal antibody that inhibits IIb/IIIa

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Q

Protease-activated receptor-1 (PAR-1) antagonist

A

vorapaxar

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Q

fibrinolytic drug antidotes

A

aminocaproic acid

tranexamic acid

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Q

fibrinolytic drug antidote uses

A

dental procedures for hemophiliacs

control bleeding for surgery

menorrhagia

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Q

binds ATIII

A

all heparins

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Q

enoxaparin

A

LMWH

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Q

dalteparin

A

LMWH

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Q

tinzaparin

A

LMWH

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Q

fondaparinux

A

LMWH

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Q

CI in pregnancy

A

warfarin

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Q

changes PT (extrinsic)

A

warfarin

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Q

warfarin mechanism

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A

interferes w/ normal synthesis and gamma carboxylation of vitamin K dependent clotting factors (2,7,9,10,C,S)

Q

2 methods to overcome warfarin overdose

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A

vitamin K (phytonadione)

fresh frozen plasma

Q

apixaban

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A

factor Xa inhibitors

Q

rivaroxaban

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A

factor Xa inhibitors

Q

dabigatran

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A

thrombin inhibitor

Q

lepirudin

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A

thrombin inhibitor

Q

bivalirudin

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A

thrombin inhibitor

desirudin

thrombin inhibitor

argatroban

thrombin inhibitor analog of arginine

irreversibly inhibits COX

aspirin

dipyridamole

antiplatelet drug

ticlopidine

platelet ADP receptor inhibitor

clopidogrel

platelet ADP receptor inhibitor

prasugrel

platelet ADP receptor inhibitor

abciximab

IIb/IIIa inhibitor

eptifibatide

IIb/IIIa inhibitor

tirofiban

IIb/IIIa inhibitor

vorapaxar

platelet inhibitor

anagrelide

platelet inhibitor

cilostazol

platelet inhibitor

streptokinase

fibrinolytic drug

urokinase

fibrinolytic drug

alteplase

fibrinolytic drug

reteplase

fibrinolytic drug

tenecteplase

fibrinolytic drug

aminocaproic acid

fibrinolytic antidote

tranexamic acid

fibrinolytic antidote