4.2 pharm diuretics Flashcards by Lu Chen

Q

Acetazolamide is a

A

Carbonic anhydrase inhibitor

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Q

Mannitol is an

A

Osmotic diuretic

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Q

Furosemide is a

A

Loop / high ceiling diuretic

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Q

Torsemide is a

A

Loop / high ceiling diuretic

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Q

Hydrochlorothiazide is a

A

Thiazide

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Q

Chlorthalidone is a

A

Thiazide

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Q

Triamterene is a

A

Potassium sparing diuretic: ENaC inhibitor

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Q

Amiloride is a

A

Potassium sparing diuretic: ENaC inhibitor

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Q

Spironolactone is a

A

Potassium sparing diuretic/ mineralocorticoid antagonist

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Q

Eplerenone is a

A

Potassium sparing diuretic: mineralocorticoid antagonist

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Q

Tolvaptan is a

A

Antidiuretic hormone antagonist

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Q

Which drugs work on plasma side (not urine side)

A

Mineralocorticoid antagonists

spironolactone
eplerenone

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Q

Causes impaired glucose tolerance

A

Triamterene (an ENaC inhibitor)

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Q

Used for SIADH

A

Tolvaptan (ADH antagonist)

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Q

Is actually an aquaretic, not a diuretic

A

Tolvaptan (ADH antagonist)

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Q

What thiazide is more effective for hypertension

A

Chlorthalidone

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Q

CI in hepatic cirrhosis

A

Acetazolamide

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Q

CI in people with peptic ulcers

A

Spironolactone (mineralocorticoid antagonist)

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Q

Used to treat absence seizures

A

Carbonic anhydrase inhibitors (Acetazolamide)

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Q

Loop diuretic MOA

Study These Flashcards

A

Inhibit Na/K/2Cl symporter

Q

Can cause ototoxicity

Study These Flashcards

A

Loop diuretics

Q

Thiazide MOA

Study These Flashcards

A

Inhibit Na Cl symporter

Q

Where do thiazides act

Study These Flashcards

A

DCT

Q

Where do loop diuretics act

Study These Flashcards

A

TAL

Where do carbonic anhydrase inhibitors act

Proximal tubule

Can cause erectile dysfunction

Thiazides

Treat Liddle's syndrome

Triamterene | Amiloride

Hyperkalemia exacerbated if taken with ACEI or NSAIDS

Triamterene | Amiloride

Interaction with 3A4 inhibitors

Eplerenone | Tolvaptan

Used for acute kidney injury

Furosemide | Torsemide

Used for hyperaldosteronism

Spironolactone | Eplerenone

Used for edema from hepatic cirrhosis

Spironolactone | Eplerenone

Used for heart failure

Loop diuretics Thiazides Aldosterone antag Tolvaptan

Prophylaxis for crush syndrome

Mannitol

Treats acute mountain sickness

Acetazolamide

Require organic anion transporter

Furosemide Torsemide Hydrochlorothiazide Chlorthalidone

Undergoes renal elimination

Furosemide

Treats alkalosis from H+ excretion

Acetazolamide

Increases LDL and TG

Furosemide Torsemide Hctz Chlorthalidone

Causes gynecomastia

Spironolactone

Causes Neurological problems

Tolvaptan

Increases water secretion

Tolvaptan

Shouldn't use if hyperlipidemia

Loop and thiazide diuretics

Causes cranial bleeding

Mannitol

Highest fractional excretion

Loop (high ceiling)

Inhibits Na/K/2Cl

Loop diuretics

Inhibit Na/Cl

Thiazide diuretics

Tolvaptan acts on what receptor

V2

Treats hirsutism

Spironolactone