6.23 Soft Tissue Tumors

Question 1

Most common adult soft tissue sarcoma

Answer 1

Undifferentiated pleomorphic sarcoma

Question 2

Most common child soft tissue sarcoma

Answer 2

Rhabdomyosarcoma

Question 3

Most common adult soft tissue tumor

Answer 3

Lipoma

Question 4

Soft yellow mass with delicate fibrous capsule

Answer 4

Lipoma

Question 5

Can grow very large

Answer 5

Liposarcoma

Question 6

3 types of liposarcoma

Answer 6

Well differentiated
Myxoid / round cell
Pleomorphic

Question 7

Mature adipocytes with scattered atypical spindle cells

Answer 7

Well differentiated liposarcoma

Question 8

Lipoblasts (mimic fetal fat cells, round clear lipid vacuoles that indent nucleus)

Answer 8

Myxoid liposarcoma

Pleomorphic liposarcoma

Question 9

Branching capillaries

Answer 9

Myxoid liposarcoma

Question 10

t(12;16)

Answer 10

Myxoid liposarcoma

Question 11

MDM2 gene amplification (inhibits p53)

Answer 11

Myxoid liposarcoma

Question 12

Hypercellular with bizarre cells and lipoblasts with lipid vacuoles

Answer 12

Pleomorphic liposarcoma

Question 13

t(22;17)

Answer 13

Nodular fasciitis

Question 14

Rapid growth with poor defined margins, but may regress spontaneously even if poorly excised

Answer 14

Nodular fasciitis

Question 15

Cellular w/ immature appearing fibroblasts and mitotically active

Answer 15

Nodular fasciitis

Question 16

Need to rule out malignancy such as fibrosarcoma

Answer 16

Nodular fasciitis

Question 17

plumb, stellate fibroblasts in a loose myxoid stroma

Answer 17

Nodular fasciitis

Question 18

Superficial fibromatoses more common in

Answer 18

males

Question 19

Dupuytren contracture also called

Answer 19

Palmar fibromatosis

Question 20

Nodular fibroblastic proliferation with abundant dense collage

Answer 20

Superficial fibromatoses

Question 21

Peyronie disease also called

Answer 21

Penile fibromatosis

Question 22

What superficial fibromatosis does not involve a contracture

Answer 22

Plantar fibromatosis

Question 23

Deep fibromatosis is also called

Answer 23

Desmoid tumor

Question 24

Often associated with pregnancy

Answer 24

Abdominal fibromatosis

Question 25

Associated with Gardner syndrome (familial adenomatous polyposis)

Answer 25

Intra-abdominal fibromatosis | Deep fibromatosis / Desmoid tumor

Question 26

Gray/white, fibrous

Answer 26

Deep fibromatosis / Desmoid tumor

Question 27

Fibroblasts infiltrating into skeletal muscle

Answer 27

Deep fibromatosis / Desmoid tumor

Question 28

Malignant mesenchymal tumor with skeletal muscle differentiation

Answer 28

Rhabdomyosarcoma

Question 29

Most commonly occur in head/neck and GU tract

Answer 29

Rhabdomyosarcoma

Question 30

Soft, grey mass

Answer 30

Rhabdomyosarcoma

Question 31

Occurs in children <5

Answer 31

Embryonal Rhabdomyosarcoma

Question 32

Sarcoma botryoides is a subtype of

Answer 32

Embryonal Rhabomyosarcoma

Question 33

Where does sarcoma botryoides occur

Answer 33

Hollow, mucosa-lined structure such as bladder, vagina, nasopharynx

Question 34

Small round cells and rhabdomyoblasts (large, round to spindled with eosinophilic cytoplasm)

Answer 34

Embryonal Rhabomyosarcoma

Question 35

Elongated cells called "strap" or "tadpole" cells

Answer 35

Embryonal Rhabdomyosarcoma

Question 36

Usually children 5-15

Answer 36

Alveolar Rhabdomyosarcoma

Question 37

t(2;13)

Answer 37

Alveolar Rhabdomyosarcoma

Question 38

Small round cells w/ scant cytoplasm

Answer 38

Alveolar Rhabdomyosarcoma

Question 39

Involves fibrous septa that divides tumor into cell groups

Answer 39

Alveolar Rhabdomyosarcoma

Question 40

Large, bizarre cells with eosinophilic cytoplasm

Answer 40

Pleomorphic Rhabdomyosarcoma

Question 41

RMS with best prognosis

Answer 41

Botryoid | Embryonal

Question 42

RMS with worst prognosis

Answer 42

Pleomorphic | Alveolar

Question 43

Benign smooth muscle tumor

Answer 43

Leiomyoma

Question 44

Develop in 77% of women

Answer 44

Uterine leiomyomas

Question 45

Spindle cells with eosinophilic cytoplasm and cigar shaped nuclei

Answer 45

Leiomyoma | Leiomyosarcoma

Question 46

Tough, round, gray/white mass with whorled cut surface

Answer 46

Leiomyoma

Question 47

Leiomyosarcoma more in

Answer 47

females than males

Question 48

Fish flesh appearance

Answer 48

Leiomyosarcoma

Question 49

External surface is irregularly lobulated

Answer 49

Leiomyosarcoma

Question 50

Immunohistochemical stain can be used to demonstrate smooth muscle actin, which indicates muscle differentiation

Answer 50

Leiomyosarcoma

Question 51

Cigar shaped nuclei and mitotic activity

Answer 51

Leiomyosarcoma

Question 52

Deep soft tissue, often knees

Answer 52

Synovial sarcoma

Question 53

t(X;18)

Answer 53

Synovial sarcoma

Question 54

Yield a chimeric transcription factor

Answer 54

Synovial sarcoma

Question 55

Spindle cells with scant cytoplasm

Answer 55

Monophasic synovial sarcoma

Question 56

Gland-like structures formed by cuboidal epithelial cells

Answer 56

Biphasic synovial sarcoma

Question 57

Positive for keratin by immunohistochemical stain

Answer 57

Biphasic synovial sarcoma

Question 58

Occasionally mets to regional lymph nodes

Answer 58

Synovial sarcoma

Question 59

Large, grey, fleshy tumors with necrosis and hemorrhage

Answer 59

Undifferentiated Pleomorphic Sarcoma

Question 60

Undifferentiated Pleomorphic Sarcoma is formerly known as

Answer 60

Malignant fibrous histiocytoma

Question 61

Large, anaplastic, spindle to polygonal cells with bizarre nuclei

Answer 61

Undifferentiated Pleomorphic Sarcoma