6.21 RA drugs

Question 1

Inhibits AICAR->FAICAR

Answer 1

MTX

Sulfasalazine

Question 2

Causes WBC apoptosis

Answer 2

MTX

Question 3

Causes retinopathy

Answer 3

Hydroxychloroquine

Question 4

First line for RA

Answer 4

MTX

Question 5

Folate antimetabolite

Answer 5

MTX

Question 6

Decreased CVD in RA

Answer 6

MTX

Question 7

Increases adenosine

Answer 7

MTX

Question 8

Decreases NF-kB

Answer 8

MTX

Question 9

Inhibits purine(MOA) and pyrimidine(ADR) synthesis

Answer 9

MTX

Question 10

Hyperhomocysteinemia ADR

Answer 10

MTX

Question 11

Increased risk for atherosclerosis (drug and molecule)

Answer 11

MTX from hyperhomocysteinemia

Question 12

Interferes w/ neural tube formation

Answer 12

MTX

Question 13

Renal toxicity

Answer 13

MTX

Question 14

Raises pH

Answer 14

Hydroxychloroquine

Question 15

Skin reactions

Answer 15

Hydroxychloroquine

Question 16

Causes acute generalized exanthematous pustulosis (requires DC)

Answer 16

Hydroxychloroquine

Question 17

CI in pre-existing ocular disease

Answer 17

Hydroxychloroquine

Question 18

Metabolized to M1

Answer 18

Leflunomide

Question 19

Acts on pyrimidine synthesis only

Answer 19

Leflunomide

Question 20

Arrest in G1 phase

Answer 20

Leflunomide

Question 21

Long half life up to 2 years

Answer 21

Leflunomide

Question 22

Must undergo drug elimination protocol if want children

Answer 22

Leflunomide

Question 23

Causes alopecia

Answer 23

Leflunomide

Question 24

Decreases protein synthesis

Answer 24

Leflunomide

Question 25

Janus kinase inhibitor

Answer 25

Tofacitinib

Question 26

Increased risk for infections

Answer 26

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 27

Must screen for TB beforehand

Answer 27

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 28

Can form antibodies against

Answer 28

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 29

ADR - formation of autoantibodies

Answer 29

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 30

ADR cytopenias

Answer 30

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 31

DC if bleeding, fever, serious hematological abnormalities

Answer 31

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 32

Can cause neurological disorders (paresthesias, tremor, demyelination)

Answer 32

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 33

Decrease response to vaccinations

Answer 33

TNFalpha inhibitors - Infliximab - Adalimumab - Etanercept

Question 34

TNFalpha inhibitor with most ADRS

Answer 34

Infliximab

Question 35

Mouse-human chimeric Ab

Answer 35

Infliximab

Question 36

Shortest duration of action TNFalpha inhibitor

Answer 36

Etanercept

Question 37

Human Ab against TNFalpha

Answer 37

Adalimumab

Question 38

Human TNF receptor fusion protein

Answer 38

Etanercept

Question 39

TNFalpha inhibitor that causes elevated liver enzymes

Answer 39

Infliximab

Question 40

Recombinant IL1-ra

Answer 40

Anakinra

Question 41

CTLA4+IgG fusion protein

Answer 41

Abatacept

Question 42

Ab against CD20

Answer 42

Rituximab

Question 43

Ab against IL-6 receptor

Answer 43

Tocilizumab

Question 44

Can also be used for B cell leukemia/lymphoma

Answer 44

Rituximab

Question 45

Exacerbates pre-existing COPD

Answer 45

Abatacept

Question 46

Depletes B cells

Answer 46

Rituximab

Question 47

Causes mucocutaneous reactions (most severe being SJS)

Answer 47

Rituximab

Question 48

Can cause cardiac dysfunction

Answer 48

Rituximab

Question 49

Can be used for Juvenile RA

Answer 49

Tocilizumab

Question 50

Can cause extremely high liver enzymes

Answer 50

Tocilizumab

Question 51

Can cause GI perforation

Answer 51

Tocilizumab