PG and LT drugs

Question 0

PGE2 analog

Answer 0

Dinoprostone

Question 1

PGE1 analogs

Answer 1

Alprostadil
Misoprostol
Lubiprostone

Question 2

PGF2α analogs

Answer 2

Latanoprost

Carboprost

Question 3

PGI2 analog

Answer 3

Epoprostenol

Question 4

LT receptor antagonists

Answer 4

Montelukast

Zafirlukast

Question 5

LT synthesis inhibitor

Answer 5

Zileuton

Question 6

Maintains PDA

Answer 6

Alprostadil

Question 7

Treats ED

Answer 7

Alprostadil

Question 8

Treats ulcers caused by NSAIDs

Answer 8

Misoprostol

Question 9

Used to induce labor or terminate pregnancy

Answer 9

Misoprostol

Dinoprostone

Question 10

Used to only terminate pregnancy (doesn’t induce labor)

Answer 10

Carboprost

Question 11

Chronic constipation or IBS with constipation

Answer 11

Lubiprostone

Question 12

Used to expel fetus after its death

Answer 12

Dinoprostone

Question 13

Treats open angle glaucoma

Answer 13

Latanoprost

Question 14

Treats ocular hypertension

Answer 14

Latanoprost

Question 15

Decrease post partum bleeding

Answer 15

Carboprost

Question 16

Treats long term pulmonary hypertension

Answer 16

Epoprostenol

Question 17

Treats asthma attacks

Answer 17

Montelukast
Zafirlukast
Zileuton

Question 18

Used to treat allergic rhinitis

Answer 18

Montelukast

Zafirlukast

Question 19

Infants with RDS should not take

Answer 19

Alprostadil

Question 20

Men with heart disease shouldn’t take

Answer 20

Alprostadil

Carboprost

Question 21

Pregnant women with NSAID induced ulcers shouldn’t take

Answer 21

Misoprostol

Question 22

Pregnant woman who have pregnancy complications or increased risk of rupture can’t take

Answer 22

Misoprostol

Dinoprostone

Question 23

People with GI obstruction shouldn’t take

Answer 23

Lubiprostone

Question 24

People with heart disease shouldn't take

Answer 24

Carboprost

Question 25

People with lung disease shouldn't take

Answer 25

Carboprost

Question 26

People with active pelvic inflammatory disease shouldn't take

Answer 26

Carboprost

Question 27

People with active kidney disease shouldn't take

Answer 27

Carboprost

Question 28

People with active liver disease shouldn't take

Answer 28

Carboprost Zileuton Caution with Zafirlukast

Question 29

Breast feeding women shouldn't take

Answer 29

Montelukast | Zafirlukast

Question 30

Alcoholics should be wary of taking

Answer 30

Zileuton

Question 31

Alprostadil has a drug interaction with

Answer 31

Ibuprofen (decreases PG production, so counteracts activity of alprostadil)

Question 32

Alprostadil acts on what receptors

Answer 32

EP 2, 3, 4 for infants | EP 2, 4 for ED

Question 33

Adverse side effects of babies taking alprostadil

Answer 33

``` Apnea Flushing Bradycardia Tachycardia Hypotension ```

Question 34

Misoprostol receptor

Answer 34

EP3 agonist

Question 35

Mechanism of Misoprostol for ulcers

Answer 35

Parietal cells secrete less acid | Mucus cells increase bicarb

Question 36

Adverse side effect of Misoprostol when used for ulcers

Answer 36

Diarrhea first 2 weeks

Question 37

Oxytocin should not be given to people taking

Answer 37

Misoprostol Dinoprostone Carboprost

Question 38

Contraindications for using Misoprostol or Dinoprostone for pregn term or induce labor

Answer 38

``` Pregnancy complications Increase risk of rupture - prior c section - placenta previa - multiple gestations ```

Question 39

Mechanism of lubiprostone

Answer 39

Activates CLC2 channels on apical GI epithelial cells Cl rich secretions softens stool

Question 40

Dinoprostone receptor activity

Answer 40

EP3 receptor agonist

Question 41

Adverse side effects of epoprostenol

Answer 41

Flushing Headache Low BP N/V

Question 42

Effects of epoprostenol

Answer 42

Vasodilates pulmonary artery | Decrease platelet agg

Question 43

Churg Strauss syndrome can be caused by

Answer 43

Montelukast

Question 44

Montelukast and zafirlukast receptor action

Answer 44

CysLT1 rec antagonist