Chemo drugs 3 MOA

Question 0

Rituximab

Answer 0

Monoclonal Ab against CD20

Question 1

Imatinib

Answer 1

Tyrosine kinase inhibitor of bcr-abl and c-Kit

Question 2

Cyclophosphamide

Answer 2

Alkylate DNA

Question 3

Ifosfamide

Answer 3

Alkylate DNA

Question 4

Cisplatin

Answer 4

Covalently bind to DNA

Question 5

Carboplatin

Answer 5

Covalently bind to DNA

Question 6

Cytarabine

Answer 6

Inhibit DNA pol

Question 7

Methotrexate

Answer 7

Inhibit dihydrofolate reductase

Question 8

5-FU

Answer 8

Inhibit thymidylate synthase

Question 9

Doxorubicin

Answer 9

Free radical formation
DNA intercalation
Topo II interaction

Question 10

Irinotecan

Answer 10

Inhibit topo I so get ss breaks

Question 11

Vincristine

Answer 11

Bind tubulin so inhibit microtubule formation

Question 12

Paclitaxel

Answer 12

Promotes microtubule assembly but inhibits depolymerization

Question 13

Docetaxel

Answer 13

Promotes microtubule assembly but inhibits depolymerization

Question 14

Erlotinib

Answer 14

Inhibit EGFR tyrosine kinase so cell cycle arrest and inhibit angiogenesis

Question 15

Sunitinib

Answer 15

Inhibits many tyrosine kinases so antiprolif and anti angiogenic

Question 16

Temsirolimus

Answer 16

Inhibits mTOR therefore growth arrest

Question 17

Arsenic trioxide

Answer 17

Differentiates

Question 18

Treating in

Answer 18

Differentiates

Question 19

Bortezomid

Answer 19

Proteasome inhibitor

Question 20

Carfizomib

Answer 20

Proteasome inhibitor

Question 21

Tamoxifen

Answer 21

Estrogen antagonist

Question 22

Anastrozole

Answer 22

Blocks aromatase from converting androgens to estrogens

Question 23

Bicalutamide

Answer 23

Binds to androgen receptors in prostate

Question 24

Leuprolide

Answer 24

LHRH analog (increases LH and FSH for a week, and then down)

Question 25

Bevaclizumab

Answer 25

Binds VEGF (inhibits tumor angiogenesis)

Question 26

Cetuximab

Answer 26

Binds EGFR and inhibits tumor growth, angiogenesis, and metastasis

Question 27

Trastuzumab

Answer 27

Binds HER2 receptor and causes cell cycle arrest

Question 28

Ado-trastuzumab

Answer 28

Delivers DM1 (microtubule inhibitor) into cells with HER2 receptor

Question 29

Ipilimumab

Answer 29

Binds to PD1 (negative regulator of T cells) and augments T cell prolif an activation

Question 30

Pembrolizumab

Answer 30

Binds CTLA (negative regulator of T cells) and increases T cell activation and prolif

Question 31

Rituximab

Answer 31

Binds CD20 on B cells | Causes cell lysis

Question 32

Tositumomab

Answer 32

IgG conjugated to radioactive iodine 131

Question 33

Erythropoietin

Answer 33

Enhances RBC production | Causes differentiation of erythroid progenitors in bone marrow

Question 34

Filgrastim & pegfilgrastim

Answer 34

Stimulates neutrophil production