6.1 cns pharm Flashcards by Lu Chen

Q

MAO-A is in

A

Liver, brain

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Q

COMT substrates

A

DA
NE
Epi
Levodopa

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Q

MAO-B is in

A

Brain, platelets

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Q

MAO-A substrates

A

Catecholamines
5HT
Tyramine

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Q

MAO-B substrates

A

DA

Tyramine

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Q

Alzheimer’s NTs

A

Loss of ACh

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Q

Huntington’s NT

A

Loss of ACh

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Q

Parkinson’s NT

A

Loss of DA, which inhibit ACh, so increase ACh

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Q

Schizophrenia NT

A

Excess dopamine

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Q

ADHD NT

A

Low DA and NE

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Q

Depression NTs

A

Low DA, NE, serotonin

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Q

Addiction NT

A

Increased dopamine

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Q

Anxiety NTs

A

Low NE, 5HT, GABA

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Q

Nausea/vomiting NT

A

5HT on vagus and CTZ

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Q

Serotonin receptor in schizophrenia

A

5HT2A

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Q

Serotonin receptor in CTZ for nausea and vomiting

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A

5HT3

Q

Major inhibitory NT in CNS

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A

GABA

Q

Strychnine is antagonist of what NT

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A

Glycine

Q

Glycine antagonist

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A

Strychnine

Q

Principle fast excitatory NT

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A

Glutamate

Q

Opioid receptor subtypes

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A

Mu
Kappa
Delta
Epsilon

Q

Opioid receptor: analgesia

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A

Mu and kappa

Q

Opioid receptor: sedation

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A

Mu

Q

Opioid receptor: hypnosis

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A

Kappa

Opioid receptor: euphoria

Mu

Opioid receptor: dysphoria

Kappa

Opioid receptor: significant respiratory depression

Mu

Opioid receptor: less respiratory depression

Kappa

Triad of opioid overdose

Unconsciousness Respiratory depression Miosis

Anandamide is an

Endocannabanoid

Endocannabanoid receptor

CB1