Pharm 2

Question 0

Comparing maximum response of 2 drugs

Answer 0

Efficacy or intrinsic activity

Question 1

Comparing ED50 of 2 drugs looks at

Answer 1

Potency

Question 2

An agent that doesn’t increase a response or potency by itself, but if added to another drug, increases response or potency

Answer 2

Potentiation

Question 3

Effect of 2 drugs more than additive effects

Answer 3

Synergism

Question 4

Rapid decrease in response after many administrations

Answer 4

Tachyphylaxis

Question 5

Examples of drugs that exhibit tachyphylaxis

Answer 5

Nitro glycerine

Tyramine

Question 6

Slow decrease in response to drug after many administrations (curve shifts right and or down)

Answer 6

Tolerance

Question 7

ED50 is dependent on

Answer 7

Affinity for the receptor

Intrinsic activity

Question 8

Intrinsic activity vs efficacy

Answer 8

Intrinsic activity - max response when all receptors occupied
Efficacy - max response before all receptors occupied

Question 9

A chemical antagonist that has many positively charged proteins and interacts and inhibits heparin

Answer 9

Protamine

Question 10

Chemical antagonist that’s a heavy metal chelator

Answer 10

Dimercaprol

Question 11

Type of antagonism that gives parallel rightward shift

Answer 11

Equilibrium competitive antagonism

Question 12

Type of antagonism that gives right and downward shift

Answer 12

Nonequilibrium competitive antagonism

Question 13

Type of antagonism that shifts graph downward

Answer 13

Non competitive antagonism

Question 14

Type of agonist that has negative efficacy (will decrease constitutive activity)

Answer 14

Inverse agonist

Question 15

Type of agonism involving activation of GPCR

Answer 15

Functional selectivity / biased agonism

Question 16

Agonist that acts and positive and negative agonist depending on amount of constitutive activity present

Answer 16

Protean agonist