8.3 Nephritic

Question 1

characteristics of nephritic syndromes that are not in nephrotic

Answer 1

red blood cell casts

elevated Cr

Question 2

what strains of GAS are nephritogenic

Answer 2

1, 4, 12 (have M protein)

Question 3

post strep glomerulonephritis is a subset of

Answer 3

acute proliferative glomerulonephritis

Question 4

immune complex mediated: deposits Ag/Ab complexes

Answer 4

acute proliferative glomerulonephritis

Question 5

diffuse proliferation / hypercellular glomerular cells, WBC influx

Answer 5

acute proliferative glomerulonephritis

Question 6

IgG, IgM, C3 in mesangium and along GBM

Answer 6

poststrep glomerulonephritis

Question 7

subepithelial electron dense humps on EM

Answer 7

poststrep glomerulonephritis

Question 8

hypercellular and enlarged glomerulus

Answer 8

poststrep glomerulonephritis

Question 9

Henoch Schonlein purpura is a subset of

Answer 9

IgA nephropathy, which is in Type II RPGN

Question 10

Wegener is a subset of

Answer 10

Type III (pauci-immune) RPGN

Question 11

Goodpasture syndrome is a subset of

Answer 11

Type I (anti-GBM) RPGN

Question 12

post infectious glomerulonephritis is a subset of

Answer 12

Type II (immune complex) RPGN

Question 13

lupus nephritis is a subset of

Answer 13

Type II (immune complex) RPGN

Question 14

cellular and fibrous crescents

Answer 14

RPGN

Question 15

linear deposits of IgG and C3 in GBM

Answer 15

Type I (anti-GBM) RPGN

Question 16

antigen to NC1 domain of alpha 3 chain of collagen type IV

Answer 16

Goodpasture syndrome (type I RPGN)

Question 17

both renal and pulmonary (hemoptysis) involvement

- & how to treat

Answer 17

Goodpasture syndrome

plasmapheresis

Question 18

granular / lumpy bumpy pattern on IF

Answer 18

Type II (immune complex) RPGN

Question 19

lack Ab or immune complexes

Answer 19

Type III (pauci-immune) RPGN

Question 20

IgA nephropathy also called

Answer 20

Berger disease

Question 21

older children and young adult with gross hematuria after an infection of respiratory, GI, or urinary tract

Answer 21

IgA nephropathy (Berger disease)

Question 22

hematuria on and off

Answer 22

IgA nephropathy (Berger disease)

Question 23

IgA in mesangium

Answer 23

IgA nephropathy (Berger disease)

Question 24

person w/ gluten allergy more susceptible to

Answer 24

IgA nephropathy (Berger disease) 
- increase synthesis of IgA

Question 25

person w/ liver disease more susceptible to

Answer 25

``` IgA nephropathy (Berger disease) - decreased clearance of IgA ```

Question 26

hematuria then chronic renal failure, nerve deafness, eye disorders - dx - what eye problems - inheritance - molecular defect

Answer 26

Alport syndrome lens dislocation, posterior cataracts, corneal dystrophy usually X linked recessive type IV collagen

Question 27

basket weave on EM

Answer 27

Alport

Question 28

lamination and splitting

Answer 28

Alport

Question 29

hematuria found on routine urinalysis (2 names)

Answer 29

Thin basement membrane disease (benign familial hematuria)

Question 30

mutated alpha3 or alpha4 chain of type IV collagen

Answer 30

Thin basement membrane disease (benign familial hematuria)

Question 31

enlarged, gray, waxy kidney

Answer 31

amyloidosis

Question 32

Henoch Schonlein has what on IF

Answer 32

IgA in mesangium (diff than IgA nephropathy because has skin lesions and arthralgia)

Question 33

IgG, IgM, IgA, C3, C1q positive

Answer 33

lupus nephritis

Question 34

what is most likely to progress to chronic glomerulonephritis

Answer 34

RPGN

Question 35

symmetrically smaller kidneys with granular surface and thin cortex

Answer 35

chronic glomerulonephritis

Question 36

bad effects of dialysis

Answer 36

arterial intimal thickening calcium oxalate crystals cysts increased adenomas and adenocarcinomas